Lift is a popular Scala based web framework with particularly powerful Comet support.
Support for Scalate has been added to Lift in the Scala 2.8.0 branch. For more details see ticket 475.
There is a helloscalate sample which shows you how you can integrate Scalate views into Lift
The trick to enabling Scalate is to enable the ScalateView in your Boot.scala class such as in this example.
The following code should do the trick
new ScalateView.register